Publications

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2023
    • Ciulla MG, Sambrotta M, Gazzola J, Marchini A, Gelain F “Low-Power Microwaves: a Cell-Compatible Physical Treatment to Enhance Self-Assembling Peptides Mechanical Properties.” Nanoscale 15: 15840-15854. doi: 10.1039/D3NR02738D
    • Forouharshad M, Raspa A, Marchini A, Ciulla MG, Magnoni A, Gelain F “Biomimetic Electrospun Self-Assembling Peptide Scaffolds for Neural Stem Cell Transplantation in Neural Tissue Engineering” Pharmaceutics 15(9): 2261. doi:10.3390/pharmaceutics15092261
    • Ciulla MG, Fontana F, Lorenzi R, Marchini A, Campone L, Sadeghi E, Paleari A, Sattin S, Gelain F “Novel self-assembling cyclic peptides with reversible supramolecular nanostructures” Materials Chemistry Frontiers doi: 10.1039/D3QM00198A
    • Buzzaccaro S, Ruzzi V, Gelain F, Piazza R “A light scattering investigation of enzymatic gelation in  self-assembling peptides” Gels 9 (4): 347-36. doi: 10.3390/gels9040347
    •  Fontana F, Carlino C, Malik A, Gelain F “Morphoscanner2.0: a new python module for analysis of molecular dynamics simulations” PLoS ONE 18(4): e0284307. doi: 10.1371/journal.pone.0284307
    •  Marchini A, Ciulla MG, Antonioli B, Agnoli A, Bovio U, Visnoviz V, Bertuzzi F, Gelain F “Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels” Frontiers in Bioengineering and Biotechnology 11:1105157. doi: 10.3389/fbioe.2023.1105157
    • Ciulla MG and Gelain F “Structure-Activity Relationships of Antibacterial Peptides” Microbial Biotechnology 16 (4): 757-777. doi: 10.1111/1751-7915.14213
2022
    • Profico DC, Gelati M, Ferrari D, Sgaravizzi G, Ricciolini C, Projetti-Pensi M, Muzi G,   Cajola L, Copetti M, Ciusani E, Pugliese R, Gelain F, Vescovi AL “Human neural stem cell-based drug products: clinical and non-clinical characterization” International Journal of Molecular Sciences 23: 13425. doi: 10.3390/ijms232113425
    • Fontana F and Gelain F “Modeling of supramolecular biopolymers: leading the in-silico revolution of tissue engineering and nanomedicine” Nanotechnology Reviews 11: 2965-2996. doi: 10.1515/ntrev-2022-0455
    • Ciulla MG, Pugliese R, Gelain F “Boosted Cross-Linking and Characterization of High-Performing Self-Assembling Peptides” Nanomaterials 12(3):320. doi: 10.3390/nano12030320
    • Pugliese R, Montuori M, Gelain F “Bioinspired Photo-Crosslinkable Self-Assembling Peptide with pH-Switchable “On−Off” Luminescence” Nanoscale Advances doi: 10.1039/d1na00688f
    • Pugliese R, Gelain F “Programmable Stiffness and Stress–Relaxation of Cross-linked Self-Assembling Peptide Hydrogels” Journal of Applied Polymer Science 139(9): 51759. doi: 10.1002/app.51759.
2021
    • Pugliese R, Gelain F, Arnoldi A, Lammi C “Chemistry and functional roles of food protein hydrogels” Food Proteins and Peptides: Emerging Biofunctions, Food and Biomaterial Applications. Royal Society of Chemistry, London, UK. 157-172. Book Chapter doi:10.1039/9781839163425-00157
    • Nobile MS, Fontana F, Manzoni L, Cazzaniga P, Mauri G, Saracino G, Besozzi D, Gelain F “HyperBeta: a novel tool for the investigation of the kinetic behavior of self-assembling peptides” Scientific Reports 11(1), 1-10 doi: 10.1038/s41598-021-87087-0
    • Marchini A, Gelain F “Synthetic scaffolds for 3D cell cultures and organoids: applications in regenerative medicine” Critical Reviews in Biotechnology 1-19. doi:10.1080/07388551.2021.1932716
    • Gelain F, Luo Z, Rioult M, Zhang S “Self-assembling peptide scaffolds in the clinic” NPJ Regenerative Medicine 6(1):9 doi: 10.1038/s41536-020-00116-w.
    • Raspa A, Carminati L, Pugliese R, Fontana F, Gelain F “Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries” Journal of Controlled Release 330: 1208-1219 doi: 10.1016/j.jconrel.2020.11.027.
2020
    • Raspa A, Gelain F “Mimicking extracellular matrix via engineered nanostructured biomaterials for neural repair” Current Neuropharmacology 19 (12), 2110-2124  doi: 10.2174/1570159X18666201111111102.
    • Gelain F, Zhongli L, Zhang S “Self-assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel” Chemical Reviews 120 (24): 13434-13460 doi: 10.1021/acs.chemrev.0c00690
    • Lau CYJ, Fontana F, Mandemaker L, Wezendonk D, Vermeer B, Bonvin A, Vries R, Zhang H, Remaut K, Dikkenberg J, Medeiros-Silva J, Hassan A, Perrone B, Kuemmerle R, Gelain F, Hennink W, Weingarth M, Mastrobattista E “Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides” Communications Chemistry 3 (1): 1-10. doi: 10.1038/s42004-020-00417-7
    • Pugliese R, Moretti L, Maiuri M, Romanazzi T, Cerullo G, Gelain F “Superior Mechanical and Optical Properties of a Heterogeneous Library of Cross-Linked Biomimetic Self-Assembling Peptides” Materials & Design doi: 10.1016/j.matdes.2020.108901
    • Pugliese R, Gelain F “Cross-linked Self-Assembling Peptides and Their Post-Assembly Functionalization via One-pot and In Situ Gelation System.” International Journal of Molecular Sciences 21, 4261: 1-15 doi: 10.3390/ijms21124261
    • Marchini A, Favoino C, Gelain F “Multi-functionalized self-assembling peptides as reproducible 3D cell culture systems enabling differentiation and survival of various human neural stem cell lines.” Frontiers in Neuroscience 14: art.413 doi: 10.3389/fnins.2020.00413
    • Dellafiora L, Pugliese R, Bollati C, Gelain F, Galaverna G, Arnoldi Anna, Lammi C “Bottom up” strategy for the identification of novel soybean peptides with ACE-inhibitory activity” Journal of Agricultural and Food Chemistry 68 (7): 2082-2090 doi: 10.1021/acs.jafc.9b07361
    • Fontana F, Gelain F “Probing mechanical properties and failure mechanisms of fibrils of self-assembling peptides” Nanoscale Advances doi: 10.1039/c9na00621d
    • Pugliese R, Gelain F “Characterization of Elastic, Thermo-Responsive, Self-Healable Supramolecular Hydrogel made of Self-Assembly Peptides and Guar Gum” Materials and Design 186, doi: 10.1016/j.matdes.2019.108370
2019
    • Jekhmane S, Prachar M, Pugliese R, Fontana F, Medeiros-Silva J, Gelain F*, Weingarth M* “Design parameters of tissue engineering scaffolds at atomic scale” Angewandte Chemie Int. Ed.  58: 2-11. doi: 10.1002/anie.201907880
    • Pugliese R, Bollati C, Gelain F, Arnoldi A, Lammi C “A Supramolecular Approach to develop new Soybean and Lupin Peptide Nanogels with enhanced DPP-IV Inhibitory Activity” Journal of Agricultural and Food Chemistry 67 (13): 3615-3623. doi: 10.1021/acs.jafc.8b07264
    • Marchini A, Raspa A, Pugliese R, Abd El Malek M, Pastori V, Lecchi M, Vescovi AL, Gelain F “Multi-functionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries” Proc Natl Acad Sci U S A. 116 (15):7483-7492. doi: 10.1073/pnas.1818392116
    • Lammi C, Bollati C, Gelain F, Arnoldi A, Pugliese R “Enhancement of the stability and anti-DPPIV activity of hempseed hydrolysates through self-assembling peptide-based hydrogels” Frontiers in Chemistry 6, 670. doi: 10.3389/fchem.2018.00670
    • Pugliese R, Maleki M, Zuckermann RN, Gelain F “Self-assembling peptides cross-linked with Genipin: resilient hydrogels and self-standing electrospun scaffolds for tissue engineering applications” Biomaterials Science. 7, 76-91 doi: 10.1039/C8BM00825F.
2018
    • Saracino G, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F “Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-peptide structural characterization” Advanced Science. doi: 10.1002/advs.201800471.
    • Raspa A, Bolla E, Cuscona C, Gelain F “Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury” CNS Neuroscience & Therapeutics. doi: 10.1111/cns.12984
    • Pugliese R, Marchini A, Saracino G, Gelain F “Functionalization of self-assembling peptides for neural tissue engineering” Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine. Elsevier, Amsterdam, NL: 475-493. Book Chapter
2017
    • Pugliese R, Fontana F, Marchini A, Gelain F “Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels” Acta Biomaterialia. doi: 10.1016/j.actbio.2017.11.026
    • Pugliese R, Marchini A, Saracino GA, Zuckermann RN, Gelain F “Cross-linked self-assembling peptide scaffolds” Nano Research. doi: 10.1007/s12274-017-1834-6
    • Maleki M, Natalello A, Pugliese R, Gelain F “Electrospinning of a heterogeneous library of co- and self-assembling peptides” Acta Biomaterialia. 51:268-278 doi: 10.1016/j.actbio.2017.01.038
    • Pugliese R and Gelain F “Peptidic biomaterials: from self-assembling to regenerative medicine” Trends in Biotechnology. 35(2): 145-158. doi: 10.1016/j.tibtech.2016.09.004
2016
    • Raspa A, Marchini A, Vasita R, Maleki M, Pugliese R, Mauri M, Gelain F “A biocompatibility study of new nanofibrous scaffolds for nervous regeneration” Nanoscale 8: 253-265.
    • Raspa A, Pugliese R, Maleki M, Gelain F “Recent therapeutic approaches for spinal cord injury” Biotechnology & Bioengineering 113(2): 253-259. doi: 10.1002/bit.25689.
2014
    • Bradshaw M, Ho D, Fear MW, Gelain F, Wood FM, Iyer KS “Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration.” Scientific Reports doi: 10.1038/srep06903
    • Raspa A, Saracino G, Pugliese R, Silva D, Cigognini D, Vescovi A, Gelain F “Complementary Co-Assembling Peptides: from in silico studies to in vivo application.” Advanced Functional Materials 40(24): 6317-6328. doi: 10.1002/adfm.201400956
    • Cigognini D, Silva D, Paloppi S, Gelain F “Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.” Journal of Biomedical Nanotechnology 10: 309-323.
2013
    • Saracino G and Gelain F “Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides.” Journal of Biomolecular Structure & Dynamics 32(5): 759-775.
    • Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F “A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering.” New Biotechnology 30(5): 552-562.
    • Cunha C, Panseri S, Gelain F. Engineering of a 3D Nanostructured Scaffold Made of Functionalized Self-Assembling Peptides and Encapsulated Neural Stem Cells. Methods in Molecular Biology. 2013 Clifton, NJ: Book Chapter doi: 10.1007/7651_2012_2
    • Vasita R, Gelain F. “Core-sheath Fibres for Regenerative Medicine” Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering. Wiley-Scrivener Publishing, Beverly: 493-533. Book Chapter
    • Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F “Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications.” Nanoscale 5(2):704-718.
    • Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F “Nanomaterials design and tests for neural tissue engineering.” Chemical Society Reviews 42(1):225-262.
2012
    • Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A. “New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering” Nanoscale 4(9):2946-2957.
    • Zhang S, Yokoi H, Gelain F, Horii A “Designer Self-Assembling Peptide Nanofiber Scaffolds” Nanotechnology for Biology and Medicine: At the Building Block Level, Springer Science/Business Media Press, New York City: 123-147. Book Chapter
2011
    • Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F “Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold”. PLoS ONE 6(5):1-15.
    • Cunha C, Panseri S, Villa O, Silva D, Gelain F “3D culture of adult mouse neural stem cells within different functionalized self-assembling peptide scaffolds” International Journal of Nanomedicine 6: 943-955.
    • Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A “BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications.” ACS Nano 5(3):1845-59.
    • Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A “Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord.” ACS Nano 5(1): 227-236.
2010
    • Gelain F, Unsworth L, Zhang S “Slow and sustained release of active cytokines from self-assembling peptide scaffolds” Journal of Controlled Release 145(3):231-239.
    • Taraballi F, Natalello A, Campione M, Doglia SM, Paleari A, Gelain F “Glycine-spacers influence over functional motif exposure and self-assembling propensity of functionalized peptides” Frontiers in Neuroengineering 3:1-9.
2009
    • Antonini S, Vescovi A, Gelain F “Stem cells and biomaterials: the tissue engineering approach” Stem Cells & Regenerative Medicine, Springer/Humana Press, New York City. Book Chapter
    • Gelain F, Wang X, Horii A, Hucknall A, Koutsopoulos S, Zhang S “Designer self-assembling peptides scaffolds for 3-dimensional tissue cell cultures” Methods in Bioengineering, Artech House Press, Boston: 59-81. Book Chapter
    • Lowery J, Panseri S, Cunha C, Gelain F “Electrospinning for Tissue Engineering Applications” Electrospun Nanofibers Research: Recent Developments, NOVA Science Publishers, Hauppauge.: 1-18. Book Chapter
    • Cellot G, Cilia E, Cipollone S, Rancic V, Sucapane A, Giordani S, Gambazzi L, Markram H, Micaela Grandolfo, Scaini D, Gelain F, Casalis L, Prato M, Giugliano M, Ballerini L “Carbon nanotubes direct interactions with neuronal membranes ignite post spike excitability” Nature Nanotechnology 4(2):126-133.
    • Taraballi F, Campione M, Vescovi AL, Sassella A, Paleari A, Whang W, Gelain F “Effect of Functionalization on the Self-Assembling Propensity of β-Sheet Forming Peptides.” Soft Matter 5(3):660-668.
2008
    • Gelain F “Novel opportunities and challenges offered by nanobiomaterials in tissue engineering” International Journal of Nanomedicine 3(4):415-424.
    • Panseri S, Cunha C, Lowery J, Del Carro U, Taraballi F, Amadio S, Vescovi A, Gelain F “Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections” BMC biotechnology 8(39) doi:10.1186/1472-6750-8-39.
2007
    • Gelain F, Horii A, Zhang S “Designer active 3D self-assembling peptide scaffolds for regenerative medicine.” Macromolecular Biosciences 7(5):544-551.
    • Gelain F, Lomander A, Vescovi AL, Zhang S “Systematic studies of a self-assembling peptide nanofiber scaffold with other scaffolds” Journal of Nanoscience and Nanotechnology 7(2):424-434.
    • Pizzi R, Cino G, Gelain F, Rossetti D, Vescovi AL “Learning in human neural networks on microelectrode arrays.” Biosystems 88(1-2):1-15.
    • Horii A, Wang X, Gelain F, Zhang S “Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration.” PLoS ONE 2(2): e190.doi:10.1371.
2006
  • Gelain F, Bottai D, Vescovi AL, Zhang S “Designer self-assembling peptide nanofiber scaffolds for 3-D culture of adult mouse neural stem cells.” PLoS ONE 1(1): e119.doi:10.1371.
2005
  • Zhang S, Gelain F, Zhao X “Designer self-assembling peptide nanofiber scaffolds for 3D tissue cell cultures.” Seminars in Cancer Biology 15(5): 413-420.
2003
  • Bottai D, Fiocco R, Gelain F, Defilippis L, Galli R, Gritti A, Vescovi AL “Neural stem cells in the adult nervous system.” Journal of Hematotherapy & Stem Cell Research 12(6):655-670.